Nikkei ended 0.76 percent lower Thursday as investors unloaded shares amid caution ahead of the closely watched U.S. nonfarm job data due out Friday.
The 225-issue Nikkei Stock Average closed down 105.31 points, or 0.76 percent, from Wednesday at 13,694.04.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange shed 5.09 points, or 0.44 percent, to 1,153. 28.
Decliners were led by steelmakers, paper and consumer finance companies while gainers included utilities, airlines and pharmaceutical shares.