Unknown gunmen attacked a Pakistan Navy official near Karasaz area on Karachi's Shahrea Faisal on Monday.
"Security and rescue teams reached the attack site situated on the port city's main artery," Dawn News reported.
"The targeted Navy official was rushed to a hospital for treatment where he succumbed to his wounds during treatment," it added.
Police sources said that the incident appeared to be sectarian motivated, although reports in the media indicated the killing could have been the result of a failed robbery.
Earlier this month, a security guard of the Pakistan Navy was shot dead by robbers in an attack on the car of a senior navy officer in Defense Phase II.
Another Pakistan navy officer was shot dead and his Swedish wife wounded in a similar attack in September last year.
Earlier on Feb 27, a lieutenant commander of the Pakistan Navy was wounded in an attack in Karachi's Keamari area who later succumbed to his injuries.
In another incident on Feb 7 2013, a naval officer and his wife were injured in a mysterious explosion in their car near the city's Karsaz area.